Shanghai Univ. of Traditional Chinese Medicine FXR compound E2

Shanghai Univ. of Traditional Chinese Medicine FXR compound E2: sourced facts only. name: "The lead compound E2 exhibited potent FXR agonist activity with an EC50 value of 0.097 ± 0.009 μM and favorable hepatic microsomal metabolic stability." [PMID:41027177]; target: "The lead compound E2 exhibited potent FXR agonist activity with an EC50 value of 0.097 ± 0.009 μM and favorable hepatic microsomal metabolic stability." [PMID:41027177]; developer: "State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China." [PMID:41027177]; stage: "In vivo evaluation confirmed that compound E2 improved hepatic steatosis in high-fat diet (HFD)-induced MASH mouse model." [PMID:41027177]