Drug intelligence / Profile preview

Shaoling

Development stage
Unknown
Lead developer
PegBio
Administration
Oral
01

Overview

Shaoling (also known as Shaoling Capsule or Biaozhi Shaoling) is a Traditional Chinese Medicine (TCM) developed by Guizhou Bailing Enterprise Group Pharmaceutical Co., Ltd. for the treatment of psoriasis vulgaris. It is formulated from several herbal ingredients, including *Smilax glabra* and *Rehmannia glutinosa*, which are traditionally used to clear heat, cool the blood, and detoxify. In the context of psoriasis, Shaoling is thought to exert its therapeutic effects through immunomodulatory and anti-inflammatory mechanisms, potentially inhibiting the overproliferation of keratinocytes and reducing the production of pro-inflammatory cytokines such as TNF-alpha and IL-17. It has been a mainstay in Guizhou Bailing's dermatology portfolio and served as the basis for the development of the small molecule candidate BD-77, which is an optimized version of the active components found in Shaoling.

Brand names
ShaolingBiaozhi Shaoling
Other names
Shaoling capsuleShaoling jiaonangBiaozhi Shaoling Capsule
02

Targets

IL8 (C-X-C Motif Chemokine Ligand 8)VEGFA (Vascular endothelial growth factor A)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)IL-6 (Interleukin 6)

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