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shBclaf1
- Development stage
- Preclinical
- Lead developer
- Washington University School of Medicine
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
shBclaf1 is a short hairpin RNA (shRNA) designed to suppress the expression of BCLAF1 (BCL2-associated transcription factor 1) through RNA interference (RNAi). BCLAF1 is a transcriptional regulator that plays a critical role in hematopoietic stem cell (HSC) self-renewal and is often upregulated in pediatric and adult acute myelogenous leukemia (AML). In research settings, shBclaf1 is used to demonstrate that the suppression of BCLAF1 is detrimental to AML cell survival and pathogenesis. Studies have shown that AML cells expressing shBclaf1 are selectively depleted, and the loss of BCLAF1 leads to a dramatically altered genetic program associated with metabolic, apoptotic, and myeloid differentiation pathways. This tool has been utilized in preclinical research at the Washington University School of Medicine to investigate BCLAF1 as a potential therapeutic target in leukemia.
- Other names
- BCLAF1 shRNABCLAF-1 shRNABCLAF 1 shRNAshort hairpin RNA targeting BCLAF1
02
Targets
BCLAF1 (Bcl-2-associated transcription factor 1)
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