shCIRH1A lentivirus

shCIRH1A lentivirus is a research-grade gene therapy tool consisting of a lentiviral vector that delivers short hairpin RNA (shRNA) specific to the CIRH1A (Cirhin) gene. CIRH1A is a ribosomal protein that is often overexpressed in colorectal cancer and is associated with cell proliferation and survival. The lentivirus-mediated delivery of shRNA triggers the RNA interference (RNAi) pathway, leading to the degradation of CIRH1A mRNA and subsequent knockdown of the Cirhin protein. In preclinical models, such as RKO colorectal cancer cell lines, this knockdown has been shown to inhibit cell growth, induce apoptosis, and cause G1 phase cell cycle arrest. It serves as a molecular tool for studying the oncogenic potential of ribosomal proteins and exploring gene silencing as a therapeutic strategy.

Other names

lentivirus-mediated CIRH1A siRNAshRNA-CIRH1A lentivirusshRNA-CIRH-1A lentivirusshRNA-CIRH 1A lentiviruslentivirus-mediated small interfering RNAs targeting CIRH1A