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Shema oral liquid

Development stage: Preclinical
Lead developer: China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
Administration: Oral

Overview

Shema oral liquid is a traditional Chinese medicine (TCM) approved for the treatment of respiratory diseases. It is a combination of ten different herbal ingredients. Preclinical studies in a lipopolysaccharide (LPS)-induced rat model of chronic obstructive pulmonary disease (COPD) have shown that Shema oral liquid ameliorates the severity of COPD by inhibiting inflammatory responses, improving pulmonary ventilatory function, and alleviating LPS-induced lung injury. Its therapeutic mechanism involves the downregulation of DNA methyltransferase 1 (DNMT1) expression in lung tissue, and it also suppresses the levels of inflammatory cytokines such as interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha.

Other names: Shema

Targets

TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)DNMT1 (DNA (cytosine-5)-methyltransferase 1)IL1B (Interleukin-1 beta)

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