Drug intelligence / Profile preview

Shema oral liquid

Development stage
Unknown
Lead developer
China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica
Administration
Oral
01

Overview

**Shema oral liquid** is an orally administered traditional Chinese medicine formula used for respiratory diseases, with reported antitussive, expectorant, and anti-asthmatic clinical effects. It is a multi-herb preparation containing Ephedra Herba, oxgall-processed Arisaematis Rhizoma, honey-roasted Morus alba bark, Belamcandae Rhizome, fried Raphani Semen, bitter apricot seed, Cynanchum glaucescens, Scutellariae Radix, vinegar-processed Schisandrae Chinensis Fructus, and Gypsum Fibrosum. In an LPS-induced COPD rat model, Shema improved ventilatory parameters, reduced pulmonary injury and circulating inflammatory cytokines, and reduced lung DNA methyltransferase 1 expression; this DNMT1-related mechanism remains preclinical rather than a clinically validated single-target mechanism. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC9214040/))

Other names
ShemaShema oral solution射麻口服液
02

Targets

DNMT1 (DNA (cytosine-5)-methyltransferase 1)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))

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