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Shen Ling Bai Zhu San is a classic traditional Chinese medicine (TCM) formula composed of ten herbs, including *Panax ginseng*, *Poria cocos*, *Atractylodes macrocephala*, and *Dioscorea opposita*. Traditionally used to tonify the Spleen, replenish Qi, and resolve dampness, it is primarily indicated for gastrointestinal symptoms such as chronic diarrhea, fatigue, and poor appetite. In modern clinical research, the formula is being investigated for its potential to mitigate chemotherapy-induced skeletal muscle loss and functional decline in patients with advanced non-small cell lung cancer (NSCLC). It is hypothesized to work by improving nutrient absorption, modulating the gut-muscle axis, and reducing systemic inflammation associated with cancer cachexia.
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