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Shen-Ma-Yi-Zhi-Fang
- Development stage
- Preclinical
- Lead developer
- Xiyuan Hospital
- Administration
- Oral
01
Overview
Shen-Ma-Yi-Zhi-Fang (SMYZG) is a Chinese herbal prescription developed at Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, for the prevention and treatment of vascular dementia. The formulation is a four-herb combination consisting of ginseng (*Panax ginseng* C.A. Mey), *Gastrodia elata* Bl, *Euonymus alatus*, and *Ligusticum chuanxiong* Hort. Its primary active components include ginsenosides, gastrodin, ferulic acid, and quercetin. SMYZG exerts neuroprotective effects and improves learning, memory, and cognitive function by regulating multiple signaling pathways, including AMPK/PPARα/PGC-1α/UCP2, Nrf2/HO-1, HIF-1/VEGF/Notch, and VEGF/Flk-1/p8 MAPK pathways. It is typically prepared as a granule for oral administration.
- Other names
- Shen Ma Yi Zhi granule参麻益智方
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)PPARA (Peroxisome proliferator-activated receptor alpha)VEGFA (Vascular endothelial growth factor A)HIF1A (Hypoxia-inducible factor 1-alpha)HMOX1 (Heme oxygenase 1)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)
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