Drug intelligence / Profile preview

Shen-Xiong-Huang-Lian-Jie-Du-Fang

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Shen-Xiong-Huang-Lian-Jie-Du-Fang (参芎黄连解毒方) is a traditional Chinese medicine (TCM) formula. The name suggests it is a combination decoction designed to "clear heat and detoxify" (解毒), with key ingredients likely including ginseng (参, often referring to Panax ginseng or Codonopsis pilosula), Ligusticum chuanxiong rhizome (芎, Chuanxiong), and Coptis chinensis rhizome (黄连, Huanglian). This type of formula typically targets conditions associated with internal heat, inflammation, or toxin accumulation according to TCM theory. While the exact composition for this specific named formula is not found in standard references or the provided search results, similar formulas such as Huanglian Jiedu Tang are well-documented for their anti-inflammatory and detoxifying effects[6][10]. Mechanistically, these formulas act by modulating inflammatory cytokines and oxidative stress pathways. They are used primarily for symptoms like fever, irritability, mouth ulcers, gastrointestinal disturbances due to "heat," and sometimes infectious or inflammatory diseases.

Other names
参芎黄连解毒方
02

Targets

TLR4/CD14 (Toll-like receptor 4/Cluster of differentiation 14 signaling complex)AMPK (Adenosine monophosphate–activated protein kinase)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)

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