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Shenan Tongluo Decoction is a traditional Chinese medicine (TCM) herbal formula used primarily in the management of diabetic nephropathy. It is administered as a decoction and typically prescribed based on TCM syndrome differentiation. The formula is currently being studied in clinical trials for its efficacy and safety in treating diabetic kidney disease, with endpoints including 24-hour urine protein quantification, lipid profiles, blood glucose levels, and renal function markers. While the precise herbal composition and mechanism of action are not detailed in available sources, similar TCM decoctions often aim to tonify kidney qi/yin and promote blood circulation according to TCM theory. The mechanism may involve modulation of metabolic pathways relevant to diabetic nephropathy; however, specific molecular targets have not been established[6].
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