Drug intelligence / Profile preview

Shenfu + DCBI

Development stage
Preclinical
Lead developer
Ya'an Sanjiu Pharmaceutical
Administration
Intravenous
01

Overview

Shenfu + DCBI is an intravenous combination therapy based on Traditional Chinese Medicine (TCM) principles. [1-4] It consists of Shenfu injection, which is composed of ginseng and aconite, and deproteinized calf blood injection (DCBI). [2-9, 2-11, 1-4] The main active components of Shenfu injection are ginsenosides and aconitum alkaloids. [2-9, 2-11] This combination therapy was investigated in a clinical trial for patients with the Yang-Qi deficiency subtype of mild to moderate Alzheimer's disease. [1-4, 1-5] In the study, it was administered once daily for a 21-day course and was found to be effective and safe, significantly improving cognitive and functional scores compared to pre-treatment and a control group. [1-6]

Other names
Shenfu injection + deproteinized calf blood injection
02

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)JUN (Transcription factor Jun)IL1B (Interleukin-1 beta)NOS3 (eNOS)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)FGF1 (Fibroblast growth factor 1)CASP3 (Caspase-3)NFKBIA (NFKB inhibitor alpha)

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