Drug intelligence / Profile preview

shenfu injection

Development stage
Phase 4
Lead developer
Ya'an Sanjiu Pharmaceutical
Administration
Intravenous, Intramuscular
01

Overview

**Shenfu injection** is a Chinese prescription herbal injection derived from the traditional Shenfu decoction. It is a fixed multi-herb product prepared from red ginseng (*Panax ginseng*) and processed aconite root (*Aconitum carmichaeli*), containing a chemically complex mixture that includes ginsenosides and processed aconite-derived diterpene alkaloids. It is used in China as an adjunctive treatment in shock and critical-care settings, including septic shock and cardiogenic shock. Clinical studies in sepsis have reported signals for improved lactate reduction, shorter vasopressor exposure, and some hemodynamic or immunologic effects, but randomized trials have not consistently demonstrated a statistically significant 28-day mortality benefit. The product is manufactured in China by China Resources Sanjiu. ([pdfs.semanticscholar.org](https://pdfs.semanticscholar.org/a3d8/dd69c6a42fdf9d9a215a4a903d212407f539.pdf))

Brand names
Shenfu
Other names
SFIShen-Fu injectionShenfu Zhusheye参附注射液
02

Targets

NOS3 (eNOS)STAT3 (Signal Transducer and Activator of Transcription 3)LGALS3 (Galectin-3)ADRA1 (Alpha-1 adrenergic receptor family)FGF1 (Fibroblast growth factor 1)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ADRB1 (β1)

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