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Shenfuhuang decoction granules
- Development stage
- Unknown
- Lead developer
- Beijing Tcmages Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Shenfuhuang decoction granules is a Traditional Chinese Medicine (TCM) compound formulation developed by the Beijing Hospital of Traditional Chinese Medicine for the treatment of sepsis. The formula is a modification of the classic Shenfu decoction, typically comprising *Panax ginseng* (Ren Shen), *Aconitum carmichaelii* (Fu Zi), and *Rheum palmatum* (Da Huang). It is designed to address the "yang exhaustion" and "toxin-heat" states associated with severe infection and septic shock. In clinical trials, it is evaluated as an adjunctive therapy to conventional sepsis treatment, with the goal of reducing 28-day mortality and improving organ dysfunction scores such as the SOFA score. The mechanism involves modulating the systemic inflammatory response, improving microvascular perfusion, and protecting organ function.
- Other names
- Shenfuhuang CompoundShenfuhuang decoctionShenfuhuang granules
02
Targets
MAPK14 (p38 mitogen-activated protein kinase alpha)GSK3 (Glycogen synthase kinase 3 beta)AKR1B10 (Aldo-keto reductase family 1 member B10)ESR1 (ERα)
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