shengma biejia decoction

**Shengma Biejia Decoction** is a traditional Chinese medicine (TCM) multi-herb formula documented in classical medical texts such as the "Jingui Yaolue" ("Golden Chamber"), primarily used for the treatment of hematological malignancies including acute leukemia and multiple myeloma[1][4][6]. It contains six major ingredients: Cimicifuga foetida (Sheng Ma), Carapax Trionycis (Bie Jia), Pericarpium zanthoxyli (Shu Jiao), Realgar (Xiong Huang, arsenic sulfide), Glycyrrhiza uralensis (Gan Cao), and Angelica sinensis (Dang Gui)[2][5]. Mechanistically, it demonstrates anti-cancer properties through the regulation of autophagy and mitochondrial dynamics in malignant cells, notably by upregulating proteins associated with mitochondrial division and autophagy (Drp-1, Fis-1, PINK1, Parkin) in leukemia and possibly through multi-pathway modulation in other malignancies and autoimmune disease[1][5][6]. Its precise molecular mechanisms remain incompletely defined due to its complex multipotent herbal composition; it is best understood as a combination therapeutic exerting synergistic multi-target pharmacology. It is widely used as an adjunct to chemotherapy to enhance efficacy and reduce toxicity in TCM clinical practice[2][6].

Other names

SMBJDsheng-ma-bie-jia-tangshengma-biejia decoction