Drug intelligence / Profile preview

shengmai injection

Development stage
Unknown
Lead developer
Tianjin University of Traditional Chinese Medicine
Administration
Intravenous, Intramuscular, Parenteral
01

Overview

Shengmai Injection is an approved traditional Chinese medicine injectable developed and marketed by Shanghai Hutchison Pharmaceuticals for cardiovascular and shock-related indications in China. It is a multi-herb formulation derived from the classical Shengmai San prescription and contains extracts of red ginseng, ophiopogon, and schisandra. Public product information describes its intended effects as tonifying qi, nourishing yin, restoring pulse, and treating patients with patterns corresponding to palpitations, dyspnea, cold extremities, diaphoresis, threatened pulse collapse, myocardial infarction, cardiogenic shock, and infectious shock. Mechanistically, it is not a single-target drug; instead, it is presented as a complex botanical injectable with reported pharmacologic effects on cardiac function, coronary blood flow, myocardial metabolism, microcirculation, arrhythmia, inflammation, and immune modulation.

Brand names
生脉注射液Shengmai Injection
Other names
Shengmai Injection生脉注射液
02

Targets

MMP9 (Matrix metalloproteinase-9)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)JNK (Mitogen-activated protein kinase kinase kinase family)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)EGFR T790M (Epidermal growth factor receptor T790M mutant)CASP3 (Caspase-3)

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