Drug intelligence / Profile preview

shengmai injection + thymosin

Development stage
Preclinical
Lead developer
Tianjin University of Traditional Chinese Medicine
Modality
Peptides
Administration
Intravenous, Intramuscular, Subcutaneous
01

Overview

Shengmai Injection + thymosin is a combination therapy consisting of Shengmai Injection—a modern injectable formulation derived from the traditional Chinese medicine prescription Shengmai San—and thymosin, an immunomodulatory peptide. Shengmai Injection contains extracts from Panax ginseng, Ophiopogon japonicus, and Schisandra chinensis. Its active components include ginsenosides (from ginseng), Maidong saponin (from Ophiopogon), and schisandrin (from Schisandra). The mechanism of action for Shengmai Injection involves replenishing Qi and nourishing Yin according to TCM theory; pharmacologically, it exerts cardioprotective effects by improving circulation, protecting cardiomyocytes against ischemia-reperfusion injury and apoptosis, reducing oxidative stress, modulating calcium overload in myocardial cells, enhancing contractility, and supporting endothelial function[2][5][6]. Thymosin is a family of peptides known for their role in modulating immune responses—particularly by promoting T-cell differentiation and function. The combination has been studied primarily in China as an adjunctive treatment to improve immune function in patients with sepsis or cancer-related fatigue[1][7]. Clinical studies suggest that this combination may enhance cellular immunity (notably increasing T cell subgroups) and improve general condition in patients with severe infections or malignancies.

Other names
Shengmai Injection combined with ThymosinShengmai San injection plus thymosin
02

Targets

AGTR2 (AT2)

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