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Shengqing Jiangzhuo capsule
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Shengqing Jiangzhuo capsule (SQJZ) is a traditional Chinese medicine prescription that has demonstrated potential in alleviating chronic kidney disease (CKD) and diabetic nephropathy (DN). It is a compound capsule, with Quercetin identified as one of its main components. In CKD, SQJZ alleviates intestinal inflammation by downregulating CHAC glutathione-specific γ-glutamylcyclotransferase 1 (CHAC1) and subsequently inactivating the hypoxia-inducible factor 1 (HIF-1) pathway. For diabetic nephropathy, it exerts protective effects by activating the Keap1/Nrf2/ARE signaling pathway. Additionally, it has been shown to alleviate chronic renal failure symptoms by inhibiting the PI3k/Akt pathway, specifically by targeting PIK3R1, and by regulating the expression of NLRP3, caspase1, AQP1, and AQP2.
- Other names
- Shengqing JiangzhuoShengqing Jiangzhuo颗粒
02
Targets
CHAC1 (Glutathione-specific gamma-glutamylcyclotransferase 1)KEAP1 (Kelch-like ECH-associated protein 1)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)AQP1 (Aquaporin-1)AQP2 (Aquaporin-2)CASP1 (Caspase-1)HMOX1 (Heme oxygenase 1)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)PIK3R1 (Phosphatidylinositol 4-phosphate 3-kinase regulatory subunit alpha)GCL (Gamma-glutamylcysteine Synthetase)
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