Drug intelligence / Profile preview

Shenkui Tongmai Granules

Development stage
Unknown
Lead developer
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Shenkui Tongmai Granules is a Traditional Chinese Medicine (TCM) formulation developed by the Jiangsu Provincial Hospital of Traditional Chinese Medicine for the treatment of chronic heart failure (CHF). It is specifically indicated for patients presenting with the TCM syndrome of Qi deficiency and blood stasis. The preparation is typically used as an adjunctive therapy alongside guideline-directed medical treatments. Its therapeutic mechanism, based on TCM principles, involves tonifying Qi, warming Yang, and promoting blood circulation to resolve stasis, thereby improving cardiac function and alleviating symptoms such as dyspnea and fatigue. Clinical evaluation, including multi-center randomized controlled trials (e.g., ChiCTR2100044900), has focused on its efficacy in improving NYHA functional class, 6-minute walk distance, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels.

Other names
Shenkui Tongmai Keli参魁通脉颗粒
02

Targets

TP53 (Cellular Tumor Antigen p53 R175H)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)

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