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Shenqi Membrane Kidney Granules
- Development stage
- Phase 1
- Lead developer
- Longhua Hospital Shanghai University of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Shenqi Membrane Kidney Granules (also known as Shenqi particle or Shenqi Mo Shen Keli) is a traditional Chinese medicine (TCM) herbal formula developed by Longhua Hospital Affiliated to Shanghai University of TCM. It is formulated to strengthen the spleen and drain dampness, and is primarily investigated for the treatment of idiopathic membranous nephropathy (IMN). The formula consists of multiple herbal ingredients, including Radix Astragali (Huangqi), Radix Codonopsis (Dangshen), and Rhizoma Dioscoreae (Shanyao). In clinical studies, Shenqi Membrane Kidney Granules has demonstrated efficacy in reducing proteinuria and protecting podocytes, showing comparable therapeutic effects to standard immunosuppressive regimens (such as prednisone and cyclophosphamide) with a superior safety profile.
- Other names
- Shenqi Mo Shen KeliShenqi Moshen GranulesShenqi Moshen KeliShenqi particle参芪膜肾方参芪膜肾颗粒
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)BCL-2 (BCL-2 family)CASP3 (Caspase-3)EGFR (Epidermal growth factor receptor)HSP90AA1 (Heat shock protein HSP90-alpha)IGF-1R (Insulin-like growth factor 1 receptor)NOTCH (Neurogenic locus notch homolog protein 3)RELA (Nuclear Factor Kappa B Subunit p65)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)
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