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Shenqing capsule
- Development stage
- Unknown
- Lead developer
- Longhua Hospital Shanghai University of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Shenqing capsule (also known as Shenqing Jiaonang) is a Traditional Chinese Medicine (TCM) formulation developed by Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine for the treatment of ulcerative colitis (UC). The capsule is primarily indicated for patients with mild to moderate active UC. It is composed of herbal extracts, typically including *Radix Ginseng* and *Indigo Naturalis*, which are intended to clear heat, detoxify, and promote the healing of the intestinal mucosa. The therapeutic effects are thought to be mediated through the modulation of the immune response, reduction of pro-inflammatory cytokines, and activation of the aryl hydrocarbon receptor (AhR) pathway to enhance intestinal barrier function. Clinical evaluation has included multicenter, randomized, double-blind trials comparing its efficacy and safety to standard treatments like mesalazine.
- Brand names
- Shenqing capsule
- Other names
- Shenqing JiaonangShen-Qing capsule
02
Targets
AHR (Aryl hydrocarbon receptor)TNFA (Tumor necrosis factor alpha (soluble))
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