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Shenshuai II granule
- Development stage
- Unknown
- Lead developer
- Shuguang Hospital
- Administration
- Oral
01
Overview
Shenshuai II is a Traditional Chinese Medicine (TCM) herbal formulation developed by Shuguang Hospital, affiliated with the Shanghai University of Traditional Chinese Medicine. It is prepared as a granule for oral administration. The formula is specifically designed to treat chronic kidney disease (CKD), particularly chronic glomerulonephritis at stage 3. Shenshuai II is based on traditional principles of tonifying the spleen and kidney while clearing dampness and resolving blood stasis. Clinical research, including the trial ChiCTR2000037052, focuses on its ability to delay the progression of renal failure, reduce proteinuria, and stabilize the glomerular filtration rate (GFR) in patients with impaired kidney function.
- Other names
- Shenshuai IIShenshuai No. 2 granuleShenshuai 2Shenshuai2Shenshuai-2肾衰II号颗粒
02
Targets
TLR4 (Toll-like receptor 4)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)PPARA (Peroxisome proliferator-activated receptor alpha)Interleukin-1 beta / Myc proto-oncogene protein axisHIF1A (Hypoxia-inducible factor 1-alpha)
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