Drug intelligence / Profile preview

Shenxianshengmai Oral Liquid

Development stage
Unknown
Lead developer
Buchang Pharmaceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

Shenxianshengmai Oral Liquid is a Traditional Chinese Medicine (TCM) herbal formulation developed and manufactured by Shaanxi Buchang Pharmaceutical. It is composed of eight specific herbal ingredients: *Panax ginseng*, *Epimedium brevicornu*, *Psoralea corylifolia*, *Lycium barbarum*, *Ephedra intermedia*, *Asarum sieboldii*, *Salvia miltiorrhiza*, and *Whitmania pigra*. The drug is approved in China (CFDA approval number Z20080183) for the treatment of cardiac and cerebral vascular diseases, specifically targeting conditions such as sick sinus syndrome, sinus bradyarrhythmias, and bradycardia. Mechanistically, the formulation works by increasing heart rate and improving sinoatrial node conduction time through the modulation of the PKC/NOX-2 signaling pathway, regulation of cardiac ion channels and ATPases, and reduction of oxidative stress. It has also demonstrated protective effects against myocardial ischemia-reperfusion injury.

Brand names
Shenxianshengmai Oral Liquid
Other names
参仙升脉口服液Shenxian-Shengmai Oral LiquidShenxian Shengmai Oral Liquid
02

Targets

KCNMA1 (Calcium-activated potassium channel subfamily M alpha member 1)KCNJ2 (Inward rectifier potassium channel Kir2.1)GJA1 (Connexin43 Hemichannel)Misfolded SOD1HCN4 (Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4)PRKCI (Protein kinase C iota)SERCA/PMCA (Calcium-transporting ATPase (Ca2+/Mg2+-ATPase))KCNQ1 (Potassium voltage-gated channel subfamily KQT member 1)KCNH2 (Voltage-gated potassium channel subfamily H member 2)ADRB1 (β1)GCL (Gamma-glutamylcysteine Synthetase)CAMK2D (Calcium/calmodulin-dependent protein kinase II delta)

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