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Shenxiong Huanglian Detoxification Formula (SHDG) is a multi-herb traditional Chinese medicine (TCM) granule developed by Professor Li Hao and manufactured by Beijing Chunfeng Chinese Medicine Co., Ltd. The formula is composed of five botanical ingredients: Renshen (*Panax ginseng*), Chuanxiong (*Ligusticum wallichii*), Huanglian (*Coptis chinensis*), Zhizi (*Gardenia jasminoides*), and Bingpian (*Borneolum Syntheticum*). It is designed based on TCM theories regarding kidney deficiency, blood stasis, and toxin accumulation in the pathogenesis of Alzheimer's disease. SHDG is currently being evaluated in clinical trials for the treatment of mild-to-moderate Alzheimer's disease, often in combination with the conventional drug donepezil, employing a multitarget approach to address neurodegeneration.
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