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Shenxiong Huanglian detoxification granules
- Development stage
- Preclinical
- Lead developer
- The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Shenxiong Huanglian detoxification granules (SXHLJD) is a Traditional Chinese Medicine (TCM) formula developed by the Third Affiliated Hospital of Guangzhou University of Chinese Medicine for the treatment of Alzheimer's disease. The preparation is a modified version of the classic Huanglian Jiedu Decoction, enriched with *Panax ginseng* and *Ligusticum chuanxiong*. It is designed to address the TCM syndromes of phlegm-stasis and toxin-internal resistance associated with cognitive decline. Mechanistically, the formula has been shown to improve cognitive function in animal models by modulating the gut-brain axis, inhibiting microglial activation, and suppressing the NLRP3 inflammasome pathway, which leads to a reduction in neuroinflammation and amyloid-beta (Aβ) deposition. It is currently utilized as a registered hospital preparation in China and is undergoing further clinical and preclinical evaluation.
- Other names
- Shenxiong Huanglian Jiedu granulesSXHLJD参芎黄连解毒颗粒
02
Targets
Aβ (Amyloid-beta peptides and aggregates)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
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