Shenyang Pharma Univ. EP4 compound 27i

Shenyang Pharma Univ. EP4 compound 27i: sourced facts only. name: "The most promising compound 27i exhibited the best inhibitory activity against EP4 (27i hEP4 IC50 = 6.40 nM)." [PMID:40976187]; target: "The most promising compound 27i exhibited the best inhibitory activity against EP4 (27i hEP4 IC50 = 6.40 nM)." [PMID:40976187]; developer: "Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China." [PMID:40976187]; stage: "In a mouse model of arthritis (AIA) induced by Freund's complete adjuvant (CFA), compound 27i significantly reduced the swelling of paws and joints, inflammatory cell infiltration, cartilage damage, pannus formation and bone erosion in the joints of AIA mice in a dose-dependent manner." [PMID:40976187]