Drug intelligence / Profile preview

Shenyang Pharma Univ. GSK-3β compound 21

Development stage
Preclinical
Lead developer
Shenyang Pharmaceutical University
01

Overview

Shenyang Pharma Univ. GSK-3β compound 21: sourced facts only. name: "The results indicated that compound 21 has the most potent inhibition against eeAChE (IC50 = 0.20 ± 0.02 μM), hAChE (IC50 = 0.34 ± 0.01 μM) and GSK-3β (IC50 = 1.14 ± 0.05 μM) among these compounds." [PMID:36191431]; target: "The results indicated that compound 21 has the most potent inhibition against eeAChE (IC50 = 0.20 ± 0.02 μM), hAChE (IC50 = 0.34 ± 0.01 μM) and GSK-3β (IC50 = 1.14 ± 0.05 μM) among these compounds." [PMID:36191431]; developer: "Teaching Hospital of Shenyang Pharmaceutical University, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China." [PMID:36191431]; stage: "Compound 21 also attenuated the tau hyperphosphorylation in the Tau (P301L) 293T cell model." [PMID:36191431]

02

Targets

GSK3 (Glycogen synthase kinase 3 beta)

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