Drug intelligence / Profile preview

Shenyankangfu + losartan potassium

Development stage
Preclinical
Lead developer
Merck
Modality
Small Molecules
Administration
Oral
01

Overview

Shenyankangfu + losartan potassium is a combination therapy consisting of Shenyankangfu tablets, a traditional Chinese patent medicine, and losartan potassium, an angiotensin II receptor blocker (ARB). This combination is primarily used in the treatment of chronic glomerulonephritis. Clinical studies and meta-analyses indicate that the combination provides superior efficacy compared to either agent alone for reducing proteinuria, improving renal function markers (such as blood urea nitrogen and serum creatinine), and lowering adverse reaction rates. - **Shenyankangfu tablets** are formulated from multiple herbal ingredients according to traditional Chinese medicine principles. They are indicated for symptoms such as proteinuria, hematuria, edema, and Qi-Yin deficiency syndrome in chronic glomerulonephritis patients[2][3]. The mechanism involves multi-target modulation including anti-inflammatory effects and improvement of renal microcirculation[4]. - **Losartan potassium** is a well-established ARB that blocks angiotensin II type 1 receptors to reduce vasoconstriction and aldosterone secretion. It lowers blood pressure, reduces proteinuria by decreasing intraglomerular pressure, protects kidney function in diabetic nephropathy or chronic kidney disease patients[5][6][7]. The combined use leverages both the renoprotective effects of ARBs with the multi-modal benefits of traditional Chinese medicine.

Other names
Shenyankangfu tablets + losartan potassiumSYKFT + losartan potassium
02

Targets

AGTR1 (Angiotensin II Type-1 receptor)

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