Shenyu enema decoction

Shenyu enema decoction is a Traditional Chinese Medicine (TCM) herbal formulation administered rectally as an enema. It is currently under clinical investigation for the treatment of ulcerative colitis. As a TCM enema, it is believed to deliver active herbal compounds directly to the colon, thereby bypassing hepatic first-pass metabolism and exerting local and systemic therapeutic effects. These effects are thought to include anti-inflammatory actions, modulation of the immune response, and potential influence on the gut microbiota, which are relevant to its use in inflammatory bowel diseases like ulcerative colitis.