Drug intelligence / Profile preview

Shenyu enema decoction

Development stage
Phase 1
Lead developer
Jiangsu Provincial Administration of Traditional Chinese Medicine
Administration
Rectal, Enema
01

Overview

Shenyu enema decoction is a Traditional Chinese Medicine (TCM) herbal formulation administered rectally as an enema. It is currently under clinical investigation for the treatment of ulcerative colitis. As a TCM enema, it is believed to deliver active herbal compounds directly to the colon, thereby bypassing hepatic first-pass metabolism and exerting local and systemic therapeutic effects. These effects are thought to include anti-inflammatory actions, modulation of the immune response, and potential influence on the gut microbiota, which are relevant to its use in inflammatory bowel diseases like ulcerative colitis.

02

Targets

NF-κBPI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT (RAC-alpha serine/threonine-protein kinase)TLR4 (Toll-like receptor 4)

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