Drug intelligence / Profile preview

Shexiang Baoxin Pill

Development stage
Phase 4
Lead developer
Shanghai Hutchison Pharmaceuticals
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Sublingual
01

Overview

Shexiang Baoxin Pill (SXBXP) is a widely used Traditional Chinese Medicine (TCM) formula primarily indicated for the treatment of cardiovascular diseases, including stable angina pectoris and coronary heart disease. It is composed of seven ingredients: artificial musk, ginseng, styrax, cinnamon bark, toad venom, calculus bovis, and borneol. The drug exerts its therapeutic effects through multiple mechanisms, including the promotion of angiogenesis (via upregulation of VEGF and bFGF), improvement of vascular endothelial function, reduction of inflammatory responses, and regulation of lipid metabolism. It has been extensively studied in China, including the large-scale MUST trial, which demonstrated its safety and efficacy in reducing major adverse cardiovascular events (MACE) in patients with stable coronary artery disease.

Brand names
Shexiang Baoxin PillShexiang Baoxin Wan
Other names
Musk Heart-Protecting PillSXBXP
02

Targets

CYP2B6 (Cytochrome P450 2B6)CYP2C19 (Cytochrome P450 2C19)OATP1B1 (Organic anion transporting polypeptide 1B1)

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