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Shexiang Huayu Xingnao (麝香化瘀醒脑颗粒) is a traditional Chinese medicine hospital preparation, formulated as granules. It is composed of multiple herbal ingredients, including musk (麝香), astragalus (黄芪), alisma (泽泻), notoginseng (三七), cinnamon twig (桂枝), and raw rhubarb (生大黄). The formula is designed to "invigorate blood circulation, resolve stasis, and awaken the brain," with musk serving as the principal herb for opening orifices and restoring consciousness. Astragalus replenishes vital energy; alisma and notoginseng promote diuresis and blood circulation; cinnamon twig warms channels; raw rhubarb purges accumulation. The main clinical indication is for neurological conditions such as stroke or cerebral hemorrhage, aiming to improve consciousness disturbance by modulating inflammation, reducing cerebral edema, improving microcirculation, and protecting neural tissue[9][1]. Mechanistic studies suggest effects on pathways like TLR4/MyD88/NF-κB signaling in brain tissue[4].
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