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shGPX3-39
- Development stage
- Preclinical
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies
- Administration
- Intraperitoneal
01
Overview
shGPX3-39 is a short hairpin RNA (shRNA)-based gene knockdown construct specifically designed to target murine glutathione peroxidase 3 (GPX3) mRNA and reduce its expression in preclinical models. Its mechanism of action consists of RNA interference that silences GPX3, a critical antioxidant enzyme. In mouse models of ovarian cancer, stable transfection with shGPX3-39 in tumor cells results in significantly decreased GPX3 expression, reduced tumor burden, and delayed accumulation of ascites, highlighting that GPX3 supports tumor progression and dissemination in vivo. shGPX3-39 is an experimental genetic reagent used in mechanistic oncology and metabolic studies, not a pharmaceutical product.
- Other names
- TRCN0000076539TRCN-0000076539TRCN 0000076539
02
Targets
GPX3 (Glutathione peroxidase 3)
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