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shHba-a1

Development stage: Preclinical
Modality: Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics

Overview

shHba-a1 is a short hairpin RNA (shRNA) designed to induce RNA interference, specifically targeting the Hba-a1 gene. The Hba-a1 gene encodes for the alpha subunit of hemoglobin A1, a protein primarily involved in oxygen transport. In the provided context, shHba-a1 is utilized as a research tool in an RNA interference screen to investigate novel immune checkpoint inhibitor molecules arising on T cells during the development of aggressive hepatocellular carcinoma.

Targets

Hb (Hemoglobin)

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