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shICAM1

Development stage: Preclinical
Lead developer: University of Texas MD Anderson Cancer Center
Modality: Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intratumoral

Overview

shICAM1 is a short hairpin RNA (shRNA) therapeutic candidate designed to knockdown the expression of Intercellular Adhesion Molecule-1 (ICAM-1, CD54). Developed by researchers at the UT MD Anderson Cancer Center, it is primarily investigated for the treatment of glioblastoma. ICAM-1 is a cell adhesion glycoprotein that is often overexpressed in tumors resistant to anti-angiogenic therapies like bevacizumab, particularly in mesenchymal glioma stem cells. By utilizing a lentiviral delivery system to deliver the shRNA, shICAM1 aims to suppress tumor invasion and migration, thereby prolonging survival and potentially overcoming resistance to VEGF-targeted treatments.

Other names: ICAM1 shRNAICAM-1 shRNAICAM 1 shRNA

Targets

ICAM1 (Intercellular Adhesion Molecule 1)

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