Shigella flexneri 2a 2457T

Shigella flexneri 2a 2457T is a virulent, wild-type bacterial strain utilized primarily as a challenge agent in Controlled Human Infection Model (CHIM) clinical trials. Developed and managed in research contexts by PATH, this specific strain is administered orally to healthy adult volunteers to induce experimental shigellosis under controlled conditions. The primary purpose of using this strain is to evaluate the protective efficacy of candidate vaccines and to investigate the biological mechanisms of naturally acquired or cross-protective immunity against different Shigella serotypes. The 2457T strain is a well-characterized isolate that causes bacillary dysentery by invading the colonic mucosa and triggering a robust inflammatory response. In PATH-sponsored studies, it serves as a critical benchmark for assessing heterologous protection between S. flexneri 2a and S. sonnei.

Other names

Shigella flexneri strain 2457TS. flexneri 2a 2457T