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shIGF2
- Development stage
- Unknown
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Implant
01
Overview
shIGF2 is a short hairpin RNA (shRNA) construct designed to silence the expression of Insulin-like Growth Factor 2 (IGF2) via RNA interference. In oncological research, particularly in studies of the tumor microenvironment, shIGF2 is utilized to investigate the role of stromal-derived IGF2 in promoting the growth and tumorigenicity of cancer cells, such as non-small-cell lung carcinoma (NSCLC). By knocking down IGF2 in fibroblasts, researchers have demonstrated a significant reduction in the growth rate of associated tumor cells, highlighting the IGF2 pathway as a potential mediator of carcinoma-stromal interactions. This reagent is primarily used as a laboratory tool to study gene function and stromal-tumor crosstalk in preclinical models.
- Other names
- IGF2 shRNAIGF-2 shRNAIGF 2 shRNAshort hairpin RNA targeting IGF2
02
Targets
IGF2 (Insulin-like growth factor 2)
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