Drug intelligence / Profile preview

Shin-yi-san + Xiao-qing-long-tang + Xiang-sha-liu-jun-zi-tang

Development stage: Unknown
Lead developer: Chang Gung Memorial Hospital
Modality: Small Molecules
Administration: Oral

Overview

This is a mixed Traditional Chinese Medicine (TCM) herbal formula consisting of three distinct classical formulas: Shin-yi-san (also known as Xin-yi-san), Xiao-qing-long-tang, and Xiang-sha-liu-jun-zi-tang. Developed and studied by Chang Gung Memorial Hospital in Taiwan, this combination is specifically investigated for the treatment of perennial allergic rhinitis. The formula exerts its therapeutic effects through complex immunomodulatory mechanisms, including the modulation of dendritic cells, CD4+ T lymphocytes, neutrophils, and regulatory B cells. It has been shown to suppress the expression of activation markers like HLA-DR, CD40, CD54, and CD86 on dendritic cells, while simultaneously enhancing the production of the anti-inflammatory cytokine IL-10 and reducing pro-inflammatory cytokines such as TNF-α, IL-4, IL-5, and IL-12. Additionally, research focuses on its impact on the gut microbiota as a potential pathway for immune regulation in allergic patients.

Other names: Xin-yi-san + Xiao-qing-long-tang + Xiang-sha-liu-jun-zi-tangTCM for Perennial Allergic Rhinitis and Gut Microbiota

Targets

CD40 (Cluster of differentiation 40 receptor)ICAM1 (Intercellular Adhesion Molecule 1)CD86 (T-lymphocyte activation antigen CD86)HLA-DR (Human leukocyte antigen DR)IL10 (Interleukin-10)IL12 (Interleukin-12)IL-4 (Interleukin 4)IL-5 (Interleukin 5)TNFA (Tumor necrosis factor alpha (soluble))

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