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Shipi Xiaoji formula

Development stage: Preclinical
Modality: Small Molecules
Administration: Oral

Overview

Shipi Xiaoji formula (SPXJF) is a Traditional Chinese Medicine formulation being investigated as a novel ferroptosis inducer in hepatocellular carcinoma. According to research approaches in network pharmacology, SPXJF has been identified as having potential to induce ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, in HCC cells. The formula represents a multi-component herbal medicine consistent with TCM treatment principles.

Other names: Shipi Xiaoji formula

Targets

LPCAT3 (Lysophosphatidylcholine acyltransferase 3)AURKA (Aurora kinase A)ACSL4 (Acyl-CoA synthetase long-chain family member 4)GSTZ1 (Glutathione S-transferase zeta 1)NOX4 (NADPH oxidase 4)SLC7A11 (Cystine-Glutamate Antiporter)ACAT1 (Acyl-coenzyme A:cholesterol O-acyltransferase 1)GPX4 (Glutathione peroxidase 4)CD46 (CD46 Molecule)CDC25A (Cell division cycle 25A phosphatase)

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