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Shiwei Anchang Granules
- Development stage
- Unknown
- Lead developer
- Jiangsu Kanion Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Shiwei Anchang Granules (十味安肠颗粒) is a Class 1.1 innovative traditional Chinese medicine (TCM) granule formulation developed for the treatment of ulcerative colitis. Formulated based on clinical experience under the guidance of TCM theory, it possesses spleen-strengthening, intestine-clearing, and antidiarrheal properties. Preclinical studies demonstrate that Shiwei Anchang Granules significantly alleviate disease activity, improve mucosal damage, and reduce histopathological lesions such as colon ulcers, inflammatory infiltration, crypt damage, and fibrotic hyperplasia in animal models of ulcerative colitis. The drug is jointly developed by Jiangsu Kanion Pharmaceutical, Shanghai Tufeng Pharmaceutical Technology, Shanghai University of Traditional Chinese Medicine, and Liaoning Beifeng Pharmaceutical.
- Other names
- Shiwei Anchang Keli十味安肠颗粒
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)EGFR (Epidermal growth factor receptor)HSP90AA1 (Heat shock protein HSP90-alpha)IL-6 (Interleukin 6)SRC (Proto-oncogene tyrosine-protein kinase Src)STAT3 (Signal Transducer and Activator of Transcription 3)
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