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Shizhen formula
- Development stage
- Phase 3
- Lead developer
- Shuguang Hospital
- Administration
- Topical
01
Overview
Shizhen formula is a Traditional Chinese Medicine (TCM) herbal preparation developed by Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine. It is specifically indicated for the treatment of anal eczema, particularly the 'damp-heat' pattern according to TCM diagnostics. The formula is designed to alleviate symptoms such as pruritus and skin lesions by modulating inflammatory pathways, specifically reducing the levels of pro-inflammatory cytokines including interleukin-4 (IL-4), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Clinical evaluation of the formula focuses on its efficacy in improving the Eczema Area and Severity Index (EASI) and the Dermatologic Quality of Life Index (DLQI) while monitoring for recurrence and side effects.
- Brand names
- Lonicera & Smilax CombinationShi Zhen Fang Capsules
- Other names
- Shizhen FangShizhen decoction
02
Targets
MAPK14 (p38 mitogen-activated protein kinase alpha)RELA (Nuclear Factor Kappa B Subunit p65)IL-4 (Interleukin 4)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))
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