ShK-Dap22

ShK-Dap22 is a synthetic peptide analog of the ShK toxin, which was originally isolated from the sea anemone *Stichodactyla helianthus*. It is designed as a potent and highly selective blocker of the voltage-gated potassium channel Kv1.3 (KCNA3). The modification involves substituting the lysine residue at position 22 with diaminopropionic acid (Dap), a change that significantly enhances its selectivity for Kv1.3 over other closely related channels such as Kv1.1, Kv1.2, and Kv3.1. ShK-Dap22 is widely utilized as a pharmacological research tool to study the role of Kv1.3 channels in immune cell functions, particularly in effector memory T cells and natural killer (NK) cells. While primarily used in preclinical research, Kv1.3 blockers like ShK-Dap22 are investigated for their therapeutic potential in treating autoimmune diseases and modulating the tumor microenvironment in cancer.

Other names

diaminopropionic acid 22-ShKShK-Dap22 peptideShK-Dap-22 peptideShK-Dap 22 peptide