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Shoc2 SMP Disruptor
- Development stage
- Preclinical
- Lead developer
- SyntheX
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Shoc2 SMP Disruptor is an early-stage small molecule developed by SyntheX Labs designed to disrupt the protein-protein interaction (PPI) complex consisting of Shoc2, MRas, and the catalytic subunit of protein phosphatase 1 (PP1c). This ternary complex serves as a critical scaffold in the Ras/MAPK signaling pathway, facilitating the dephosphorylation and activation of RAF kinases. By interfering with the assembly of this complex, the drug aims to inhibit oncogenic signaling in Ras-mutated tumors, addressing a key node of oncogene addiction and synthetic lethality. The program is currently in the Hit and Mechanism of Action (MoA) validation phase.
- Other names
- Shoc2 SMP Disruptor (PPI disruptor)Shoc2-MRas-PP1c complex disruptorShoc-2-MRas-PP1c complex disruptorShoc 2-MRas-PP1c complex disruptor
02
Targets
SHOC2 (Leucine-rich repeat protein SHOC-2)
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