Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
short hairpin RNA RHPN1-AS1
- Development stage
- Preclinical
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Inhalation, Oral, Ophthalmic
01
Overview
Short hairpin RNA RHPN1-AS1 (sh-RHPN1-AS1) is an experimental RNA interference (RNAi) agent designed to silence the long non-coding RNA (lncRNA) RHPN1-AS1. In prostate cancer models, RHPN1-AS1 is upregulated and functions as a competitive endogenous RNA (ceRNA) that sponges miR-7-5p, thereby upregulating EGFR expression and activating the PI3K/AKT/mTOR signaling pathway. By knocking down RHPN1-AS1, sh-RHPN1-AS1 restores miR-7-5p activity, leading to the downregulation of EGFR, inhibition of cell proliferation and invasion, and induction of G2/M arrest, apoptosis, and autophagy. This construct is primarily used in preclinical research to investigate the oncogenic role of RHPN1-AS1 in tumor progression.
- Other names
- RHPN1-AS1 knockdown plasmidRHPN-1-AS1 knockdown plasmidRHPN 1-AS1 knockdown plasmidshRNA targeting RHPN1-AS1
02
Targets
RHPN1-AS1 (Rhophilin Rho GTPase binding protein 1 antisense RNA 1)
Beyond the preview
Go deeper on short hairpin RNA RHPN1-AS1.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on short hairpin RNA RHPN1-AS1.