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ShotCAR CD19 is a non-viral chimeric antigen receptor (CAR) cell therapy being developed by Hauul Bio for the treatment of hematologic malignancies. Developed using Hauul Bio's proprietary ShotCAR platform, the therapy utilizes a recombinant fusion protein CAR system. Unlike traditional CAR-T therapies that rely on viral vectors for gene transduction, the ShotCAR platform independently expresses and purifies recombinant CAR proteins and introduces them directly into immune cells. This non-viral approach is designed to simplify the manufacturing process, reduce costs, and improve safety by avoiding viral integration. ShotCAR CD19 specifically targets CD19-positive malignant cells to induce their destruction. The drug is currently in the discovery/research stage of development.
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