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Shoutai Wan
- Development stage
- Unknown
- Lead developer
- Peking University Third Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Shoutai Wan is a traditional Chinese medicinal (TCM) formula utilized by the Peking University Third Hospital as part of a sequential herbal therapy to treat infertility associated with decreased ovarian reserve (DOR). The protocol is typically used as an adjuvant to in vitro fertilization and embryo transfer (IVF-ET) to improve clinical pregnancy rates and ovarian function. The therapy involves a sequential administration of herbs: initially focusing on kidney-tonifying and blood-nourishing components (such as *Semen Cuscutae*, *Radix Angelicae Sinensis*, and *Radix Rehmanniae*) during the follicular phase, followed by modifications to promote blood circulation and support the luteal phase post-embryo transfer. Its mechanism of action is thought to involve the regulation of the hypothalamic-pituitary-ovarian (HPO) axis, modulation of hormone levels including follicle-stimulating hormone (FSH) and anti-Müllerian hormone (AMH), and enhancement of the ovarian microenvironment and endometrial receptivity.
- Other names
- Sequential Therapy of Kidney Tonifying and Blood Regulating HerbsModified Shoutai WanEr Zhi Wan combined with Si Wu Tang
02
Targets
ER (Estrogen receptor)LHCGR (Luteinizing hormone/choriogonadotropin receptor)FSHR (Follicle-stimulating hormone receptor)
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