Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
shPROK1-1
- Development stage
- Preclinical
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Injection
01
Overview
shPROK1-1 is an experimental short hairpin RNA (shRNA) construct designed to silence the expression of the **PROK1** (Prokineticin 1) gene. In preclinical research, specifically in pancreatic cancer models, shPROK1-1 has been utilized to investigate the therapeutic potential of targeting the PROK1 pathway. Silencing PROK1 with this construct has been shown to inhibit tumor growth, reduce angiopoiesis, and promote apoptosis in vivo. These anti-tumor effects are associated with the inhibition of the **PI3K/AKT/mTOR** signaling pathway and the modulation of downstream molecules such as PCNA-1, cyclin D1, Bcl-2, Bax, and cleaved caspase-3. It serves as a tool for validating PROK1 as a target for pancreatic carcinoma therapy.
- Other names
- shRNA-PROK1-1shRNA-PROK-1-1shRNA-PROK 1-1PROK1 shRNAPROK-1 shRNAPROK 1 shRNA
02
Targets
PROK1 (Prokineticin 1)
Beyond the preview
Go deeper on shPROK1-1.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on shPROK1-1.