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SHR-1701 + fluazopalil
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Oral
01
Overview
SHR-1701 + fluazopalil is an investigational combination therapy being studied primarily for the treatment of lung squamous cell carcinoma. SHR-1701 is a bifunctional fusion protein that targets programmed death ligand 1 (PD-L1) and acts as a trap for transforming growth factor beta (TGFβ), thereby inhibiting both immune checkpoint and immunosuppressive TGFβ signaling pathways. Fluazopalil is presumed to be a small molecule drug, but specific details about its mechanism or class are not available in the provided sources. The combination aims to enhance antitumor immune responses by simultaneously blocking PD-L1-mediated immune evasion and TGFβ-driven immunosuppression[1][2][9]. Clinical trials are ongoing to evaluate efficacy and safety in first-line maintenance therapy for lung squamous cell carcinoma.
- Other names
- SHR-1701 combined with fluazopalilSHR1701 combined with fluazopalilSHR 1701 combined with fluazopalil
02
Targets
TGFB (GARP–latent transforming growth factor beta 1 complex)CD274 (Programmed cell death protein 1 ligand 1)
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