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SHR-A1811 + trastuzumab + pyrotinib + nab-paclitaxel
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous, Oral (pyrotinib)
01
Overview
A four-drug combination regimen consisting of SHR-A1811 (an anti-HER2 antibody-drug conjugate), trastuzumab (a humanized IgG1 monoclonal antibody targeting HER2), pyrotinib (an oral irreversible pan-ErbB receptor tyrosine kinase inhibitor), and nab-paclitaxel (nanoparticle albumin-bound formulation of paclitaxel). The combination is designed to target HER2-positive or HER2-altered cancers, such as breast and lung cancer, by leveraging multiple mechanisms: direct HER2 targeting, receptor blockade, kinase inhibition, and microtubule disruption. SHR-A1811 delivers cytotoxic agents specifically to HER2-expressing cells via antibody-drug conjugate technology. Trastuzumab blocks HER2-mediated signaling and mediates antibody-dependent cellular cytotoxicity. Pyrotinib inhibits downstream signaling by irreversibly binding HER2 and EGFR family kinases. Nab-paclitaxel disrupts microtubule dynamics, inhibiting cell division. The regimen is under investigation in clinical trials for HER2-positive and HER2-mutant solid tumors[1][2][3][7].
- Brand names
- HerceptinAbraxaneAiruini
- Other names
- SHR-A1811 ADCSHR-A-1811 ADCSHR-A 1811 ADCtrastuzumab IVtrastuzumab SCpyrotinib maleatenanoparticle albumin-bound paclitaxel
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)ERBB2 (Erb-b2 receptor tyrosine kinase 2)MicrotubuleTOP1 (DNA Topoisomerase I)ERBB4 (Erb-b2 receptor tyrosine kinase 4)
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