shRNA against NRF2

shRNA against NRF2 is a gene-silencing therapeutic approach designed to downregulate the expression of Nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor encoded by the NFE2L2 gene. NRF2 serves as a master regulator of the cellular antioxidant response, and its overactivation is a common feature in various cancers, where it promotes tumor survival, metabolic reprogramming, and resistance to chemotherapy and radiation. By delivering short hairpin RNA (shRNA) sequences—often via viral vectors like lentivirus or non-viral systems like lipid nanoparticles—the RNA interference (RNAi) machinery is engaged to degrade NRF2 mRNA. This reduction in NRF2 protein levels compromises the ability of cancer cells to neutralize reactive oxygen species (ROS), thereby sensitizing them to oxidative stress-inducing therapies and inhibiting tumor progression.

Other names

shNRF2shNRF-2shNRF 2NRF2 shRNANRF-2 shRNANRF 2 shRNANFE2L2 shRNANFE-2L2 shRNANFE 2L2 shRNAshort hairpin RNA targeting NRF2