shRNA-IGF2-AS

shRNA-IGF2-AS is an experimental **short hairpin RNA therapy** designed to silence **insulin-like growth factor 2 antisense RNA (IGF2-AS)**, a long noncoding RNA reported to be overexpressed in pancreatic cancer models. In the cited preclinical study, depletion of IGF2-AS reduced pancreatic cancer cell proliferation, migration, invasion, epithelial-mesenchymal transition, tumor growth, and metastasis, consistent with an RNA-interference mechanism that lowers IGF2-AS and secondarily downregulates the **IGF2-IGF2R signaling axis**. The available evidence appears to be limited to research-use preclinical knockdown experiments rather than a named clinical-stage or commercial drug program.

Other names

IGF2-AS shRNAIGF-2-AS shRNAIGF 2-AS shRNAshort hairpin RNA targeting IGF2-ASshRNA targeting insulin-like growth factor 2 antisense RNA