shROR1 lentivirus

shROR1 lentivirus is a gene therapy tool consisting of a lentiviral vector expressing short hairpin RNA (shRNA) designed to silence the expression of Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1). ROR1 is a type I transmembrane protein often overexpressed in various malignancies, including glioblastoma (GBM) and glioma stem cells (GSCs), where it promotes tumorigenesis, self-renewal, and therapeutic resistance. By delivering shRNA into target cells, the lentivirus triggers the RNA interference (RNAi) pathway to degrade ROR1 mRNA, thereby inhibiting downstream signaling pathways such as the ROR1-GRB2-ERK-c-Fos axis. In preclinical models of glioblastoma, knockdown of ROR1 via this lentiviral approach has been shown to impair GSC proliferation and inhibit tumor growth.

Other names

ROR1-targeting shRNA lentivirusROR-1-targeting shRNA lentivirusROR 1-targeting shRNA lentiviruslentiviral shRNA targeting ROR1