SHS gel

SHS gel is a multifunctional composite hydrogel developed by researchers at Xiang'an Hospital of Xiamen University, specifically designed for the treatment of infected wounds. The formulation consists of a silk fibroin (SF) and hyaluronic acid (HA) matrix integrated with silver nanoparticles (AgNPs). The silk fibroin and hyaluronic acid provide a biocompatible, porous scaffold that mimics the extracellular matrix, promoting cell adhesion, migration, and proliferation. The silver nanoparticles provide broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains, by disrupting bacterial membranes and generating reactive oxygen species. This combination aims to accelerate wound closure, reduce inflammation, and prevent infection in chronic and acute wound scenarios.

Other names

Silk fibroin/hyaluronic acid/silver nanoparticle hydrogel